David Tennant has played both Hamlet and the Tenth Doctor, and this video combines the two to flesh out the Doctor's tragedy with Shakespeare's words. It couldn't be more appropriate in describing the struggles of Tennant's Doctor, who both fights to preserve himself in his current incarnation and yet also puts his life at risk on purpose many times because he keeps losing everything.
I'm old enough to know that a longer life isn't always a better one. In the end, you just get tired; tired of the struggle, tired of losing everyone that matters to you, tired of watching everything you love turn to dust. If you live long enough, the only certainty left is that you'll end up alone.